Turkish Journal of Geriatrics 2021 , Vol 24, Issue 4
THE EFFECTS OF THIAZIDE AND THIAZIDELIKE DIURETICS ON THE RELATIONSHIP BETWEEN NORMAL SERUM URIC ACID LEVELS AND COGNITIVE FUNCTION
Fatma Özge KAYHAN KOÇAK1, Seval AY2, Elif ERTUNA3, Mehmet Zuhuri ARUN3, Sevnaz ŞAHİN1, Zeliha Fulden SARAÇ1, Selahattin Fehmi AKÇİÇEK1
1Ege University, Division of Geriatrics, Department of Internal Medicine, izmir, Turkey
2Istanbul Medeniyet University, Division of Oncology, Department of Internal Medicine, istanbul, Turkey
3Ege University, Department of Clinical Pharmacy, Faculty of Pharmacy, izmir, Turkey
DOI : 10.31086/tjgeri.2021.250 Introduction: The objective of this study was to identify the possible effect of thiazide and thiazide-like diuretic use on the relationship between uric acid and cognitive function in geriatric patients with normal renal function.

Method: Serum uric acid levels and Mini-Mental State Examination scores of 238 patients (age ?65 years) treated in an outpatient geriatric clinic were evaluated in this observational, cross-sectional, retrospective study. The effect of thiazide diuretic use on Mini-Mental State Examination score was also assessed.

Results: Compared to patients that are not currently taking thiazide diuretics (non-thiazide group) serum uric acid was significantly higher in patients using thiazide and thiazide-like diuretics (thiazide group) (5.27±0.12 vs 6.09±0.20; P< 0.001). Although the serum uric acid levels were higher in the thiazide group the Mini-Mental State Examination scores were similar to the non-thiazide group. There was a strong positive correlation between serum uric acid levels and Mini-Mental State Examination score in both groups (P< 0.001). The Mini-Mental State Examination score was significantly lower in the lowest serum uric acid quartile in both groups (P< 0.001).

Conclusions: Low serum uric acid levels are associated with cognitive impairment; a slight but significant increase of serum uric acid due to thiazide diuretic use does not seem to enhance cognitive function in geriatric patients. Keywords : Dementia; Cognitive Dysfunction; Geriatric Assessment; Uric Acid; Sodium Chloride Symporter Inhibitors; Aged