Materials and Method: A total of 105 patients aged ?65 years who were hospitalized with community-acquired pneumonia between 2020 and 2025 were included in this retrospective cohort study, and their clinical, laboratory, and demographic data were collected. Prognostic performance for 30-day mortality was assessed using receiver-operating characteristic curves, Area Under the Receiver Operating Characteristic Curve and Kaplan?Meier survival analyses.
Results: C-reactive protein-to-albumin ratio demonstrated the highest discriminatory ability, followed by prognostic nutritional index and neutrophilto- lymhocyte ratio. Although elevated platelet lymphocyte ratio was associated with reduced survival rates (p=0.038), none of the novel biomarkers remained independent predictors in multivariate Cox regression analyses.
Conclusion: C-reactive protein-to-albumin ratio is a simple, cost-effective, and highly predictive biomarker for in-hospital mortality in elderly patients with community-acquired pneumonia, outperforming other indices and complementing conventional scores. Estimation of C-reactive protein-toalbumin ratio may facilitate early risk stratification and guide interventions in this population.
Keywords : Community-Acquired Pneumonia; Inflammation Mediators; Biomarkers; Prognosis; Aged