Turkish Journal of Geriatrics 2022 , Vol 25, Issue 4
DIAGNOSTIC AND PREDICTIVE ROLE OF PLATELET/LYMPHOCYTE RATIO (PLR) IN PREDICTING OUTCOMES IN ELDERLY COVID-19 PATIENTS (A CROSS-SECTIONAL STUDY)
Esra AKDAŞ TEKİN1, Fethi GÜLTOP1, Onur OKUR1, Sinan MUTLU1, Ayla YEŞİLOVA2, Namigar TURGUT1
1Prof.Dr.Cemil Taşcıoğlu City Hospital, Anesthesiology and Reanimation Clinic, İstanbul, Turkey
2Prof.Dr.Cemil Taşcıoğlu City Hospital, Clinic of Internal Medicine, İstanbul, Turkey
DOI : 10.31086/tjgeri.2022.313 Introduction: In this study, we aimed to investigate the prognostic effects of platelet-to-lymphocyte ratio biomarker in the group of laboratory-confirmed Coronavirus Disease-19 (COVID-19) geriatric patients and compare them with the group of patients under 75 years of age.

Material and methods: The platelet-to-lymphocyte ratio were recorded for oxidative stress response when it is decided to transfer patients from the emergency room COVID-19/area to the COVID-19 /service, at the time of admission to intensive care unit due to arterial oxygen partial pressure (PaO2 mmHg) to fractional inspired oxygen (FiO2) < 200 mmHg, at the time of discharge from intensive care unit and exitus.

Results: It was found that the mean age of the survivors was significantly lower than those who had died (p = 0,016). In Post-hoc analysis, the plateletto- lymphocyte ratio values at hospitalization of ? 75years old patients who had died were found to be significantly different compared to patients 75 < years (p = 0.006)who were survived and patients 75 ? years who had died (p = 0.043). Only hospitalization platelet-to-lymphocyte ratio value and age data were found to be associated with mortality. According to mortality;the cut-off value for platelet-to-lymphocyte ratio at the time of admission to the COVID-19/ service in patients 75 ? years at the time of admission to ICU in patients 75 < years was determined as 411.15 and 216.54, respectively.

Conclusion: The clinical use of the platelet-to-lymphocyte ratio may be a suitable marker in geriatric patients for determining disease severity and can be used as a predictive factor for determining the poor prognosis. Keywords : Aged; Platelet Count; Lymphocytes; COVID-19