Turkish Journal of Geriatrics 2022 , Vol 25, Issue 4
IS DYNAMIC THIOL/DISULFIDE HOMEOSTASIS ASSOCIATED WITH THE PROGNOSIS OF GERIATRIC PATIENTS WITH SEPSIS IN THE INTENSIVE CARE UNIT?
Esra YAKIŞIK ÇAKIR1, Gamze GÖK2, Özcan EREL2, Işıl ÖZKOÇAK TURAN1
1Ankara Bilkent City Hospital, Department of Anesthesiology and Clinical of Critical Care, Ankara, Turkey
2Ankara Bilkent City Hospital, Department of Biochemistry, Ankara, Turkey
DOI : 10.31086/tjgeri.2022.307 Introduction: Sepsis is an important cause of mortality, especially in geriatric patients hospitalized in the intensive care unit. Our study aims to evaluate the effectiveness of thiol / disulfide homeostasis in determining the mortality of geriatric patients admitted to intensive care unit due to sepsis.

Materials and Method: Our study was designed prospectively in patients aged 65 years and older with geriatric sepsis hospitalized in the intensive care unit between January 2018 and March 2019. Thiol-disulfide homeostasis was measured at the time of hospitalization. Demographic and clinical characteristics and thiol ? disulfide homeostasis levels were compared in patients with mortality and surviving.

Results: 252 geriatric patients with sepsis were included in the study. A total of 148 (58.7%) of the patients died, 104 (41.3%) were discharged alive. In the group with mortality, native-thiol, total-thiol and disulfide levels were found to be significantly lower compared to the surviving group (p <0.05). In geriatric patients with sepsis; levels of native-thiol less than 209 ?mol / L, total-thiol lesss than 248 ?mol / L and disulfide being less than 20.4 ?mol / L was found as the cut-off value for mortality (p=0.0001).

Conclusion: This study showed that low native-thiol, total-thiol and disulfide levels may be associated with mortality in patients with geriatric sepsis hospitalized for the first time in the intensive care unit. Keywords : Aged; Intensive Care Units; Sepsis; Sulfhydryl Compounds