Turkish Journal of Geriatrics 2006 , Vol 9, Issue 1
Hacettepe Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, ANKARA Hutchinson-Gilford progeria syndrome is a premature aging disorder. The syndrome is charecterised by growth reterdasyon and progressive, premature senescent changes of skin, bones and cardiovascular system. Patients usually present between the age of 1 and 2 years with failure to thrive, alopecia and abnormal skin. Death results from cardiovascular changes in the majority of cases. The syndrome is commonly caused by a point mutation in the lamin A gene. Keywords : Hutchinson-Gilford progeria syndrome, Progeria, Premature aging