Turkish Journal of Geriatrics 2016 , Vol 19, Issue 1
Mehmet TÜRKELİ1, Mehmet Naci ALDEMİR1, Melih ŞİMSEK1, Nilgün YILDIRIM1, Mehmet BİLİCİ1, Kerim ÇAYIR2, Salim Başol TEKİN1, HarunYETİMOĞLU3
1Atatürk University, Faculty of Medicine, Department of Medical Oncology, ERZURUM
2Mevlana University, Faculty of Medicine, Department of Medical Oncology, KONYA
3Atatürk University, Faculty of Medicine, Department of Internal Medicine, ERZURUM
Introduction: Elderly patients are under-represented in the clinical trials of patients with metastatic gastric cancer (GC); therefore, the efficacy and tolerability of palliative chemotherapy are unclear in these patients. We aimed to assess the efficacy and tolerability of first-line palliative chemotherapy in elderly patients (age ≥70 years) with metastatic GC.

Materials and Method: From 2005 to 2014, 89 patients with metastatic GC who were 70 years and older and were treated with at least two cycles of systemic chemotherapy as first-line treatment were included retrospectively. Disease and patient characteristics, prognostic factors, treatment response, grade 3–4 toxicity related to treatment, progression free survival (PFS), and overall survival (OS) were evaluated.

Results: Of the 89 patients, 65 (73%) were males; median age was 74 (70–84) years. The median follow-up period was 7 months (min–max: 2–57 months), median PFS was 5 months (95% CI: 3.7–6.3), and median OS was 7 months (95 % CI: 5.2–8.9). The disease was controlled in 43.8% patients, whereas progression was observed in 56.2% patients. Univariate analysis showed that the Eastern Cooperative Oncology Group (ECOG) performance status, number of chemotherapy cycles, and response to the first line chemotherapy had a significant effect on PFS and OS; liver metastasis had an effect only on PFS; lung metastasis had an effect only on OS.

Conclusion: Fewer chemotherapy cycles, lung metastasis, liver metastasis, and poor ECOG performance scores were found to be poor prognostic factors. Keywords : Stomach Neoplasms; Neoplasm Metastasis; Aged; Drug Therapy