Turkish Journal of Geriatrics 2017 , Vol 20, Issue 1
BIOMARKERS OF ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA SIMULTANEOUSLY SAMPLED FROM SERUM AND CEREBROSPINAL FLUID
Ömer KARADAŞ1, Güray KOÇ2, Akçay Övünç ÖZÖN1, Bilgin ÖZTÜRK1, Dildar KONUKOĞLU1
1 Gulhane Training and Research Hospital, Neurology, ANKARA
2Gaziler Physical Medicine and Rehabilitation Training and Research Hospital, Neurology, ANKARA
3Liv Hospital , Neurology ANKARA
4Haydarpasa Sultan Abdulhamit Training and Research Hospital, Neurology ISTANBUL
5Istanbul University Cerrahpasa Medical Faculty, Biochemistry, ISTANBUL
Introduction: Alzheimer’s disease, which is a progressive disease accompanied by behavioral problems and decreased activities of daily living with early cognitive decline, and vascular dementia, which is related to cerebrovascular lesions with gradual, progressive cognitive decline, are common in the elderly. Currently, pathological examination is the gold standard in both Alzheimer’s disease and vascular dementia and studies to elucidate the role of cytokines in their pathophysiology using cerebrospinal fluid and serum biological markers have been intensified. In this study, cerebrospinal fluid and serum biomarker levels from both Alzheimer’s disease and vascular dementia patients were examined.

Materials and Method: Thirty patients diagnosed with Alzheimer’s disease (Group 1) and vascular dementia (Group 2) were enrolled in this study. Serum interleukin-1β, tumor necrosis factor--α, and interleukin-6 levels as well as serum and cerebrospinal fluid protein carbonyl, glutathione and β-amyloid levels from Groups 1 and 2 (N=15 each) patients were compared.

Results: Serum interleukin-1β, tumor necrosis factor-α, and β-amyloid levels as well as serum and cerebrospinal fluid protein carbonyl and glutathione levels were not statistically different (p>0.05) between Group 1 and Group 2. Serum interlukin-6 levels and cerebrospinal fluid β-amyloid levels were significantly higher and lower, respectively, in Group 2 than in Group 1 (p<0.05).

Conclusion: In this study, serum interleukin-6 levels were higher, whereas cerebrospinal fluid β-amyloid levels were lower, in vascular dementia patients than in Alzheimer’s disease patients. Keywords : Alzheimer’s disease; Dementia, Vascular; Cytokines; Biochemical markers