2Ankara Bilkent City Hospital, Department of Biochemistry, Ankara, Turkey DOI : 10.31086/tjgeri.2022.307 Introduction: Sepsis is an important cause of mortality, especially in geriatric patients hospitalized in the intensive care unit. Our study aims to evaluate the effectiveness of thiol / disulfide homeostasis in determining the mortality of geriatric patients admitted to intensive care unit due to sepsis.
Materials and Method: Our study was designed prospectively in patients aged 65 years and older with geriatric sepsis hospitalized in the intensive care unit between January 2018 and March 2019. Thiol-disulfide homeostasis was measured at the time of hospitalization. Demographic and clinical characteristics and thiol ? disulfide homeostasis levels were compared in patients with mortality and surviving.
Results: 252 geriatric patients with sepsis were included in the study. A total of 148 (58.7%) of the patients died, 104 (41.3%) were discharged alive. In the group with mortality, native-thiol, total-thiol and disulfide levels were found to be significantly lower compared to the surviving group (p <0.05). In geriatric patients with sepsis; levels of native-thiol less than 209 ?mol / L, total-thiol lesss than 248 ?mol / L and disulfide being less than 20.4 ?mol / L was found as the cut-off value for mortality (p=0.0001).
Conclusion: This study showed that low native-thiol, total-thiol and disulfide levels may be associated with mortality in patients with geriatric sepsis hospitalized for the first time in the intensive care unit.
Keywords : Aged; Intensive Care Units; Sepsis; Sulfhydryl Compounds