Turkish Journal of Geriatrics 2005 , Vol 8, Issue 2
IMPORTANCE OF HIGH-SENSITIVITY CRP IN ELDERLY SUBJECTS WITH AND WITHOUT METABOLIC SYNDROME
Güler BUĞDAYCI, Arife POLAT DÜZGÜN, Yüksel KOCA, Sevilay SEZER, Turan TURHAN
Ankara Numune Eğitim ve Araştırma Hastanesi, II.Biyokimya Laboratuvarı
Ankara Numune Eğitim ve Araştırma Hastanesi, III. Cerrahi Kliniği C-reactive protein is a prototypic marker of inflammation. The purpose of this study is to evaluate high sensitivity C-reactive protein (hsCRP) level in elderly subjects with and without metabolic syndrome. This study was performed to compare hsCRP levels between elderly healthy subjects (n=20, 12 men, 69,5±2,4 years, group II) and elderly with metabolic syndrome (n=20, 12 men, 70,4±1,8 years, group III) and young healthy subjects (n=20, 12 men, 25,5±1,3 years, group I). Serum hsCRP levels were significantly higher in group II and group III compared to controls (p<0,001). Our findings suggest that hsCRP level in elderly subjects may be related to the severity of endothelial dysfunction. In contrast to several biomarkers that also reflect biological aspects of inflammation, hypofibrinolysis, and insulin resistance, hsCRP measurement is inexpensive, standardized, widely available and has a decadeto- decade variation similar to that of cholesterol. Keywords : Elderly, CRP, Metabolic syndrome