Turkish Journal of Geriatrics
2007 , Vol 10, Issue 1
THE MECHANISM, SIGNIFICANCE AND RELATIONSHIP WITH AGING OF PROTEIN OXIDATION
Gazi Üniversitesi Tıp Fakültesi Tıbbi Biyokimya/Merkez Laboratuvarı ANKARA
It is known that reactive oxygen species play roles at physiologic and pathologic processes.
They may damage biomolecules like proteins, lipids, DNAs and carbohydrates.
Proteins are the main target of oxidative stress. Ionized-radiation, metal-ion cathalized reactions,
photochemical process and enzyme cathalized redox reactions form the reactive oxygen
radicals which react with proteins. Hidroxyl or carbonyl derivations of aminoacid side
chain, protein-protein cross linkage and fragmantation of polypeptide chains are main results
of protein oxydation. Within these having protein carbonyl group is the most common marker
of protein oxidation.The studies made in the recent years show a relation between aging and oxygen radicals. As an example of protein damage via oxygen radicals, is the oxidative inactivation of some key metabollic enzymes in getting older. Furthermore it is known that proteins which are oxidatively modified increase in conditions like inflammatory diseases, atherosclerosis, neurologic diseases, ischemia-reperfussion damage and carsinogenesis.
Keywords : Protein oxidation, Reactive oxygen species, Aging