2Sağlık Bakanlığı Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Endokrinoloji ve Metabolik Hastalıklar Kliniği ANKARA
3Hacettepe Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı ANKARA Introduction: Obstructive sleep apnea syndrome(OSAS) and Non-Thyroidal Illness Syndrome(NTIS) are two separate disorders associated with inflammatory response to hypoperfusion/ hypoxia.We investigated the presence of NTIS in subjects with OSAS and the relationship between thyroid hormone levels and the severity of OSAS.
Materials and Method: Study group composed of 146 subjects (52 male, 94 female), who underwent polysomnography and grouped as non-OSAS (AHI<5, n=22), mild-OSAS (5≤AHI<15, n=49) and moderate-severe OSAS (AHI≥15, n=75). Thyroid ultrasound was performed and plasma levels of thyroid hormones,C-reactive protein (hs-CRP), anti-thyroglobulin and anti-thyroid peroxidase antibodies were measured.
Results: Study population consisted of 146 subjects [52/94(F/M)] with a mean age of 45,9±9.8. Oxygen desaturation index (ODI), mean and minimum oxygen saturation (minSaO2), time spent under SaO2 of<90% and hs-CRP levels were statistically different between three groups (p<0.05). Ten patients (6F/4M; %13.3) were found to have NTIS, all of them were in the moderate-severe group. Serum average TSH, free-T3 and free-T4 levels were not significantly different (p>0.05) in OSAS patients compared to non-OSA subjects.Mean age and ODI were negatively correlated with free-T4 levels (r:-189, p<0.05), while minSaO2 was positively correlated with free-T4 levels.Only age was negatively correlated with free-T3 levels.
Conclusion: NTIS is more frequent in OSAS patients and associated with the severity of OSAS. NTIS may be a predicting factor for mortality and severity of OSAS.In order to show the relationship between NTIS and OSAS, further randomized controlled studies are needed before and after treatment of OSAS.
Keywords : Aged; Euthyroid Sick Syndromes; Obstructive Sleep Apnea Syndrome