Turkish Journal of
GERIATRICS

Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi Fiziksel Tıp ve Rehabilitasyon İSTANBUL Relapsing seronegative symmetrical synovitis with pitting edema (RS3PE) is a clinical syndrome characterized by acute onset of symmetrical joint involvement with pitting edema of the hands and feet. The etiology and pathogenesis of RS3PE is still unknown, though environmental and infectious agents may play a role in its development. RS3PE might be associated with rheumatologic diseases; while coexistence of RS3PE with neoplasms is also reported. Prognosis of RS3PE is good, with high response to low dose corticosteroids. A 72 year old man, who also suffers from prostate adenocarcinoma, with RS3PE syndrome is reported. He had no symptoms of prostatism or systemic symptoms. Adenocarcinoma was detected during the investigation for a possible coexisting malignancy. He responded well to the steroid treatment. Aged patients diagnosed with RS3PE syndrome should be carefully investigated for coexistence with neoplasms and followed for a future malignant process. Low dose corticosteroids should be initiated in all patients, together with the appropriate treatment for the malignancy in patients with neoplastic RS3PE. Keywords : Aged; Prostate; Synovitis