2Minoufiya University , Community Medicine, Minoufiya, MISIR
3Minoufiya University , Medical Biochemistry, Minoufiya, MISIR
4Minoufiya University , Orthopaedic Surgery, Minoufiya, MISIR
5Minoufiya University , Rheumatology, Minoufiya, MISIR Introduction: Oxidative stress plays an important role in the pathogenesis of postmenopausal osteoporosis (PMO). Antioxidants have the ability to mitigate the damaging effects of reactive oxygen species (ROS).
Materials and Method: This study evaluated the plasma levels of two selected antioxidant defenses: vitamin C and superoxide dismutase (SOD) and Malondialdehyde (MDA) the lipid peroxidation byproduct and oxidative stress indicator in >45 years old postmenopausal osteoporotic women (n=40) as compared to non-osteoporotic controls (n=20). Subjects underwent a full history taking, clinical examination and bone mineral density (BMD) of the proximal femur and measurement of plasma vitamin C, SOD and MDA.
Results: The study showed that women with PMO had significantly lower levels of plasma vitamin C and SOD and higher MDA levels as compared to the controls (p<0.05). A significant positive correlation (p<0.01) was found between plasma vitamin C, SOD and Femoral neck BMD while a significant but negative correlation was found between MDA and femoral neck BMD.
Conclusion: Oxidative stress and decreased antioxidant defenses have an important role in the pathogenesis of PMO and MDA may be an important indicator for bone loss in postmenopausal women, necessitating further research.
Keywords : Postmenopausal osteoporosis, Oxidative stress, Antioxidant, Vitamin C, Superoxide dismutase, Malondialdehyde