Turkish Journal of Geriatrics 2010 , Vol 13, Issue 2
Hernando RAFAEL
Universidad Nacional Autònoma de Mèxico Neurosurgeon, MEXICO CITY, MEKSİKA Since 80s we know that growth hormone (GH) secretion declines with age. However, in July 1990, Rudman and colleagues reported for the first time, rejuvenation in persons over 61 years of age following the administration of GH. Since then and to date, four therapeutic methods are used against aging: 1) administration of exogenous GH; 2) administration of exogenous growth hormone-releasing hormone (GHRH); 3) administration of secretagogue products, and finally, 4) hypothalamic revascularization. With all of them, rejuvenation is evident, but in different degrees. Therefore, the aging process is a disease, which is initiated in the arcuate nucleus of the hypothalamus secondary to ischemia by atherosclerosis in supraclinoid carotids. Keywords : Aged; Arcuate nucleus/pathology; Hypothalamus/pathology; Omentum/ transplantation