Turkish Journal of Geriatrics 2017 , Vol 20, Issue 1
NEUTROPHIL-TO-LYMPHOCYTE RATIO AS A PREDICTOR OF SEVERE CORONARY ARTERY DISEASE AND LEFT VENTRICULAR SYSTOLIC DYSFUNCTION OF ANY DEGREE IN GERIATRIC PATIENTS PRESENTING TO EMERGENCY DEPARTMENT WITH ACUTE CORONARY SYNDROME
Orçun ÇİFTCİ1, Afşin Emre KAYIPMAZ1, Tolga Reşat AYDOS3, İbrahim Haldun MÜDERRİSOĞLU1
1Başkent University, Faculty of Medicine, Department of Cardiology, ANKARA
2Başkent University, Faculty of Medicine, Department of Emergency Medicine ANKARA
3Başkent University, Faculty of Medicine, Department of Medical Pharmacology, ANKARA
Introduction: We examined the role of the neutrophil-to-lymphocyte ratio (NLR) for predicting severe coronary artery disease and left ventricular systolic dysfunction of any degree in geriatric patients presenting to emergency department with non-ST-elevation acute coronary syndrome.

Materials and Method: We retrospectively reviewed data for patients aged ≥65 years with non-ST-elevation acute coronary syndrome who underwent coronary angiography between April 2011 and January 2016. Patients were divided into Group 1 (101 patients; severe [>50%] lesions in one or more epicardial artery or branch) and Group 2 (65 patients; no severe lesions). The key clinical parameters, including NLR were compared among the groups and the power of NLR as a predictor of severe coronary artery disease and left ventricular systolic dysfunction of any degree was determined.

Results: Group 1 included more patients who were male, older, or smoked; these had higher troponin I, mass CK-MB, NLR, but a lower left-ventricular ejection fraction. NLR was an independent predictor of severe coronary disease and left ventricular systolic dysfunction of any degree with good sensitivity and moderate specificity.

Conclusion: Neutrophil-to-lymphocyte ratio is a simple, rapid, and cheap parameter that can predict severe coronary artery disease and left ventricular systolic dysfunction of any degree in geriatric patients with non-ST-elevation acute coronary syndrome. Keywords : Acute coronary syndrome; Aged; Neutrophils; lymphocytes