2Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Genel Cerrahi Kliniği ANKARA
3Kafkas Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalı KARS
4Numune Eğitim ve Araştırma Hastanesi Genel Cerrahi Kliniği ANKARA
5Özel Melikgazi Hastanesi Genel Cerrahi Bölümü KAYSERİ Introduction: In this study, it was aimed to investigate the relationships between immunohistochemical parameters and axillary lymph node metastasis in female patients with breast cancer. Additionally, age related differences between patient groups were investigated.
Materials and Method: Medical records of patients who underwent surgery for breast cancer during the last ten years were evaluated. The patients were divided into two groups according to their age: above group 1and below group 2, 65 years. Patient age, tumor stage, estrogenic and progesterone receptor status, C-erbB-2 oncogene and p53 tumor suppressor gene status and axillary lymph node status were recorded and analyzed for both groups.
Results: There were 43 patients with a mean age of 72 in G1 and 148 patients with a mean age of 48 in G2. We detected a positive correlation between axillary lymph node metastasis and p53 mutation for all patients, and this correlation was statistically significant in G2 (p<0.001). Different correlations however not statistically significant were observed between the other immunohistochemical parameters and axillary lymph node metastasis.
Conclusion: Immunohistochemical parameters, particularly p53 mutation, may indicate axillary lymph node metastasis and tumor prognosis in patients with breast cancer.
Keywords : Breast Neoplasms; Geriatrics; Pathology; Lymphatic Metastasis